Whatever the route, maternal viremia seems a likely prerequisite for transplacental infection.
2.
CB4 virus has caused transplacental infections in mice.
3.
All utilize canids as definitive hosts : transplacental infection has also been reported . " S . neurona " causes equine protozoal myeloencephalitis.
4.
The mechanism of transplacental infection has been investigated by using IF microscopy to identify infected cells in maternal and fetal tissues at progressively longer intervals after maternal oronasal exposure.
5.
Low levels of antibody found to be protective allow speculation that, once the immune system has been primed with PPV, subsequent exposure to virulent virus during gestation is unlikely to result in transplacental infection even if antibody from vaccination is no longer detected.
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